Investigating the health status of cell populations with light!
Keywords: live imaging, membrane potential, neural network, zebrafish
Within the body, numerous cells are at work, and one of the indicators used to examine their function (health status) is the membrane potential. For example, in the brain, information is transmitted by the firing of nerve cells, during which very small changes in membrane potential, such as 80 millivolts, occur. By capturing these potential changes, we can investigate the state of various organs, such as the brain and heart. Until now, the mainstream method has been to insert thin electrodes into the body to record data, but we are developing "membrane potential imaging" as an effective tool for non-invasive recording in living organisms. In recent years, there has been progress in the development of sensor proteins (membrane potential sensors) that can capture the membrane potential of cells as changes in brightness or color. We are using this novel membrane potential sensor in the transparent and living tropical fish, zebrafish, to investigate cellular activity (whether they are healthy or not) through live imaging.
- Company：埼玉大学 オープンイノベーションセンター
- Price：Other
